tag:blogger.com,1999:blog-133794002011-04-21T12:57:34.293-07:00Miss Hillemannnoreply@blogger.comBlogger11100tag:blogger.com,1999:blog-13379400.post-1117817060097377902005-06-03T09:44:00.000-07:002005-06-03T10:05:57.856-07:00The following is the formation of a urea derivative (-NHCONH-), which is similar to the amide formation studied in Organic Chemistry III. This reaction is the last step in the synthesis of N-substituted 4-ureido-5,7-dichloro-quinolines (DCUKs), specifically DCUKA (N,N-(diphenyl)-4-ureido-5,7-dichloro-2-carboxy-quinoline), which is now being used in sedatives.<br /><img src="http://photos10.flickr.com/17238618_d6088cd344_m.jpg" /><br /><a href="http://jpet.aspetjournals.org/cgi/content/full/292/1/215?ck=nck#F2">Here is the reference for the above example.</a><br /><br /><br /><br /><br /><br />The following is the formation of an amide by performing the reaction of N’-(arylmethylene)- isonicotinohydrazides with pyrazine-2-carbonyl chloride in the presence of sodium hydride in toluene at reflux temperature. This is used in the formation of antimycobacterial agents.<br /><img src="http://photos14.flickr.com/17236850_c5d2487a27.jpg?v=0" /><br /><a href="http://www.arkat-usa.org/ark/journal/2005/I02_Anand/NA-1158F/NA-1158F.pdf">Here is the reference for the above example.</a><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/13379400-111781706009737790?l=jhillemann.blogspot.com' alt='' /></div>Miss Hillemannnoreply@blogger.com3