New Organic Chemistry III extra credit

The following is the formation of a urea derivative (-NHCONH-), which is similar to the amide formation studied in Organic Chemistry III. This reaction is the last step in the synthesis of N-substituted 4-ureido-5,7-dichloro-quinolines (DCUKs), specifically DCUKA (N,N-(diphenyl)-4-ureido-5,7-dichloro-2-carboxy-quinoline), which is now being used in sedatives.

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The following is the formation of an amide by performing the reaction of N’-(arylmethylene)- isonicotinohydrazides with pyrazine-2-carbonyl chloride in the presence of sodium hydride in toluene at reflux temperature. This is used in the formation of antimycobacterial agents.

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